If I play Nessa on my turn while my opponent has “Shifty Substitution” in effect, do I still get to Paralyze the opponent’s Active Pokemon if I use Drednaw’s “Vise Wave” attack?
Yes, because even though Shifty Substitution replaces Nessa’s usual effect the Supporter card still has the same name, so Vise Wave will still paralyze your opponent.
Vise WaveShifty Substitution